Manna Pre + Probiotic Liposomal Review: Is It Effective?

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It's hard to overstate the benefits of a healthy gut microbiome. It's associated with improved digestive health, decreased inflammation, better regulated immune response, and much more. A high quality prebiotic and probiotic combination supplement help restore health and balance to this vital system.

There's only one problem - quality definitely matters when it comes to choosing a supplement. If you're not getting a variety of live, active cultures, then you're not benefiting as much as you could be. That's where Manna Liposomal Pre + Probiotic can help.

Liposomal Prebiotics and Probiotics: Is It Better Than Dual Capsules?

Prebiotics and probiotics both contribute to gut health, but they're really very different. Probiotics consist of strains of beneficial bacteria, like Lactobacillus acidophilus. Prebiotics are essentially bacteria "food" -- the material that a healthy gut biome needs in order to harbor a sufficient population of beneficial bacteria.

With that out of the way, many pre- and probiotic supplements consist of dual capsules. The only problem here is that pills and powders tend to have a pretty poor uptake. Liposomal formulations, on the other hand, provide much higher absorption. Better absorption means that you're getting more out of your supplements.

Fast Facts of My Manna Pre + Probiotic Review

Manna Liposomal Pre + Probiotic

Liposomal for better absorption

Could improve gut health, digestion, immune strength, skin health, healthy aging

Includes 8 clinically studied probiotics and Inulin


What’s Manna Liposomal Pre + Probiotic All About?

pre+probiotic manna liposomal pack

Manna Liposomal Pre+Probiotic consists of packets of liquid intestinal flora supplements. It combines pre- and probiotics for maximum effectiveness, and the liposomal formulation means that it's better utilized by the body.

Its listed benefits include better gut health, relief from digestive trouble, improved immunity, improved skin clarity, and healthy aging. It contains eight different strains of beneficial bacteria, for a total of 40 billion colony forming units (CFU).

What I Like

Combining pre- and probiotics is very helpful. These key components generally come from very different foods, so it's easy to consume plenty of one and not enough of the other. If you don't eat a lot of cultured foods, like yogurt, it's easy to miss out on probiotics. If you don't eat a lot of fiber, then you'll miss out on prebiotics. Putting both in a single supplement helps fill in some of these gaps.

It's also not easy to turn live bacteria into tiny pills and have them survive the trip from the factory to the shop, to your body. Manna's liposomal formulation helps ensure that their beneficial bacteria and prebiotics actually seed your digestive system in a useful way.

The liquid formulation is also great for people who have trouble taking pills. Whether you have difficulty swallowing them, or just don't like having to take them, Manna's liquid packets make it super easy to use this supplement.

What I Don’t Like

The variety and abundance of probiotics in Manna Liposomal Pre+Probiotic is good, but it only provides one form of prebiotic: a fructan called inulin. Inulin is a polysaccharide compound (a kind of carbohydrate) made up of a chain of fructose molecules and used by many types of intestinal flora.

While inulin is a very effective and widely supplemented prebiotic, it isn't the only one out there. I would've liked to see a wider variety of different prebiotics to support a greater range of beneficial bacteria.

My Breakdown of the Formula

liposomal pre+ probiotic poured into a spoon

Manna Liposomal Pre+Probiotic's formula is pretty solid, and the liquid consistency makes it easier to use. Here's a breakdown of what goes into each packet:

8 Clinically Studied Probiotics

Your gut flora comprises over 400 different species of bacteria. Manna Liposomal Pre+Probiotic includes eight strains of bacteria that have been well-studied for their effects on human health.

Lactobacillus plantarum P90 is a beneficial bacteria that is commonly found in pickled vegetables. Research has shown that L. plantarum helps protect cells from oxidative stress, helps regulate intestinal permeability, and limits the growth of pathogenic bacteria.

Lactobacillus rhamnosus LPa05 has been shown to help regulate blood sugar in mice with type 2 diabetes. Other studies have shown some weight loss effects, improved blood lipids, and fewer symptoms of certain types of allergies.

Lactobacillus casei LC89 also helps reduce blood glucose and insulin levels in mice with type 2 diabetes by regulating the liver's glucagon response.

Lactobacillus paracasei LC86 is found in cultured dairy products. It's well known for its anti-inflammatory effects.

Bifidobacterium bifidum BBi32 is abundant in the human gut microbiome. In healthy individuals, B. bifidum can account for as much as 25% of bacteria found in waste. It has been shown to help reduce irritable bowel syndrome symptoms and improve immune response. There's some evidence that it may help with skin health, too -- one study gave B. bifidum supplements to pregnant people and newborn babies, and found that the babies given B. bifidum had dramatically lower instances of eczema when compared to those in the control group.

Bifidobacterium lactis BLa80 has been shown to help mitigate acute colitis by reducing inflammation in the intestines.

Bifidobacterium animalis BA12 is one of the most studied species of Bifidobacteria. Strains of B. animalis have been shown to improve intestinal function, guard against diarrhea, and help reduce the unpleasant side-effects of antibiotic treatment. Some studies have also demonstrated a protective effect against respiratory infections.

Bifidobacterium breve BBr60 is a strain of lactic and acetic acid-producing bacteria. It has been extensively investigated in pediatrics, but studies in adults have shown reductions in fat mass, biochemical markers for diabetes, and C-reactive protein, a marker for inflammation.


Inulin is a collection of fructose polymers. It's abundant in a variety of vegetables, especially chicory roots. It's a very safe supplement that, in most cases, produces very few side-effects.

Inulin is a prebiotic, which means that it's a food source for intestinal bacteria. It's a soluble fiber that humans can't digest at all, so it passes through the stomach pretty much untouched. That means that it gets delivered right to the intestines, where the gut flora can use it.

Since people in different geographical areas and cultures can have different gut microbiomes, supplementing prebiotics may be even more important than supplementing probiotics. This is because not all probiotic bacteria are useful to everyone, but inulin is capable of feeding and encouraging the growth of a diverse range of beneficial bacteria.

Reality Vs. Claimed Benefits

green background with manna lipzomal pre + probiotic

Probiotics talk a good game, but are they all they're cracked up to be? Not always.

The fact is, probiotics correct an imbalance in your intestinal flora. If your gut microbiome is already healthy, they're not going to make things any better. If you're experiencing health issues that aren't related to the kind of biochemical pathways that a healthy gut microbiome works on, you're probably not going to see much of a benefit there, either.

That said, processed foods are often lacking in the kind of prebiotic fiber that intestinal bacteria need to thrive. Antibiotics and other medications can also disrupt their populations. There's a lot of stuff out there that isn't super great for your gut microbiome, so there's a good chance that you'd benefit from supplementing pre- and probiotics.

It's also important to note that science is still learning a lot about how our bodies interact with our natural populations of bacteria. Some of the claims made about certain strains of probiotics are based on research on mice. What we do know is that probiotics have a very low instance of side-effects (and those side-effects are generally very mild, like gas or bloating), and the benefits that are emerging seem to greatly outweigh them.

Cost and Where to Buy

You can purchase Manna Liposomal Pre+Probiotic on Manna's website. A one-time purchase of a 30-day supply is currently $49.95 (marked down from $69.95), or you can subscribe to save 39%.

Alternative Synbiotic Supplements to Consider

If Manna's Pre+Probiotic doesn't seem like your bag, there are a number of other probiotic supplements available:

Seed Synbiotic

product - seed probiotic

Seed offers a once daily pre- and probiotic supplement for adults, and a separate formulation for children. Their DS-01® daily supplement comprises 24 different strains of probiotic, along with a prebiotic. Dosage is one capsule per day for three days, increasing to two capsules on day four. Seed's DS-01® is $49.99 for a one month supply.

ritual synbiotic plus compared to seed

Ritual's Synbiotic+ is an interesting three-in-one formula. It consists of 15 milligrams of a prebiotic, 11 billion colony forming units of probiotic bacteria, and a postbiotic. Their postbiotic is tributyrin, a compound naturally found in butter. It's said to have an adaptogenic effect that helps regulate bowel movements, promote healthy intestinal mucosa, and regulate gastric motility. Ritual's Synbiotic+ is $54 for a 30 day supply.

primal gut restore

Primal Gut Restore is also a three-in-one formula. It contains 1000 milligrams of the postbiotic tributyrin, 100 milligrams of prebiotic xylooligosaccharides, and 3 billion CFU of Bifidobacterium longum BB536®. It's available for $49.95 for a 30 day supply, or you can subscribe for 20% off.

User Reviews and Average Rating

Reviews for Manna Liposomal Pre+Probiotic are very good. Overall, the supplement has a 4.8 out of 5 with a total of 66 reviews from verified buyers.

Users cite the variety of probiotic bacteria, ease of use, and improvements in digestion or overall health. Even the lower reviews are very positive, with one user giving the supplement a 3 out of 5 but still praising the supplement's convenience and liquid formula.


How long does one order of Manna Pre+Probiotic last?

One order lasts roughly a month. Each box contains 30 packets of liquid pre- and probiotics, with a serving size of one packet per day.

If you try Manna Liposomal Pre + Probiotic and love it, you can subscribe to save money and automatically receive a new supply every 30 days. You'll spend less, and ensure that you never run out!

When is the best time to take Liposomal Pre + Probiotic?

You can take your Manna Liposomal Pre + Probiotic whenever you like -- just remember that consistency is key. It's best to take it with food, so you may wish to time things so you consume it with the same meal each day. This will help you establish a habit of taking your pre- and probiotics, so you never miss a dose.

How do I store my Manna Pre + Probiotic?

Unlike many other probiotic supplements, Manna Liposomal Pre + Probiotic doesn't require refrigeration. With that said, you should store the packets in a cool, dry area for best quality.

Is it made in the USA?

Yes! Manna Liposomal Pre + Probiotic is made in the USA from excellent ingredients sourced from around the world. Every single batch is tested for contaminants and must pass strict standards.

Closing Remarks

Blue background with greenery and manna lipsomal pre + probiotic

Prebiotic and probiotics are pretty well-researched, but there's still a lot we don't know about them yet, and plenty of strains of bacteria that have yet to be identified. Manna Liposomal Pre+Probiotic combines multiple strains of thoroughly studied beneficial bacteria plus a versatile prebiotic, all in a shelf-stable, liquid formulation that makes them easy to use. Their liposomal formula also ensures that the pre- and probiotics are more effective than powders or tablets. If you're looking for a general supplement to improve gut health, Manna Liposomal Pre+Probiotic is an affordable, helpful option.

Fit Healthy Wife

A devoted mother to two vibrant children, Fit Healthy Wife embodies the essence of health, fitness, and wellness. Juggling the demands of motherhood and professional commitments, she is a testament to the power of a balanced lifestyle. As the co-founder of Fit Healthy Reviews, she brings a touch of femininity and genuine personal experience to every product review. Her passion extends beyond just fitness, aiming to inspire and guide others on their wellness journeys. Due to her professional career, she will remain anonymous to protect herself and her family!